Of All Antioxidants, Would One Finally Be Used Clinically For Atherosclerotic Disease?

Authors

  • Suko Adiarto Departemen Kardiologi dan Kedokteran Vaskular FKUI, Pusat Jantung Nasional Harapan Kita, Jakarta.

DOI:

https://doi.org/10.30701/ijc.v34i1.303

Abstract

Oxidation of LDL by oxygen free radicals results in unregulated uptake of modified LDL by macrophages in arterial wall. This is considered a key initiating factor for development and progression of atherosclerotic process. It is then logical to hypothesize that anti-oxidants, which can directly scavenge free radicals, can be useful in preventing atherosclerotic process. Initial support for this hypothesis accumulated rapidly from numerous in-vitro studies.

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References

Hendarto, Rochman S, Sargowo D. Mangosteen Pericarp Inhibits Nuclear Factor ?B (NF-?B) Activation and Reduces Expression of ICAM-1 in High Cholesterol diet rat. J Kardiol Indones. 2013;34:23-32

Reddy KS. Diet and Cardiovascular Disease. In: Yusuf S, Cairn JA, Fallen EL, Gersh BJ, eds. Evidence-based Cardiology, 3rd ed. Singapore 2010: 111-124

Jialal I, Devaraj S. Antioxidants and Atherosclerosis: Don’t Throw 3. Out the Baby With the bath water. Circulation. 2003;107:926-928

Diaz nm, Frei b, Vita ja, Keaney jf. Antioxidants and atherosclerotic heart disease. N eng J Med. 1997;107:410-416

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Published

2013-10-16

How to Cite

Adiarto, S. (2013). Of All Antioxidants, Would One Finally Be Used Clinically For Atherosclerotic Disease?. Indonesian Journal of Cardiology, 34(1), 33–4. https://doi.org/10.30701/ijc.v34i1.303

Issue

Vol. 34, No. 1 Januari - Maret 2013

Section

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