Manfaat Suplemen Antioksidan: Fakta atau Fiksi ?
Abstract
Peranan suplemen antioksidan masih tetap kontroversial sampai saat ini. Boleh dikatakan, belum ada rilis hasil penelitian tentang manfaat antioksidan bagi penderita penyakit jantung koroner dalam jurnal-jurnal terbaru beberapa tahun belakangan ini sebagai hasil penelitian klinis mutakhir yang bisa dianggap konklusif. Manfaat antioksidan masih tetap kontroversial dan memerlukan penelitian lebih lanjut dengan disain penelitian yang lebih scrutinized dan analisis yang lebih kritis.Tidak ada isu lain di bidang terapi kardiovaskuler yang lebih kontroversial saat ini, melainkan isu tentang peranan antioksidan itu. Seorang pejabat FDA menyebutkan bahwa efektivitas antioksidan dalam pengobatan penyakit jantung memang masih tetap belum konklusif, walau pun sudah banyak penelitian yang dilakukan. Sebagian penelitian itu memang sudah menunjukkan hasil yang positif, tapi sebagian lagi masih tetap menjadi bahan perdebatan yang panjang.
Maka pertanyaan, “perlukah suplemen antioksidan diberikan secara rutin pada pasien dengan kelainan koroner – karena manfaatnya dan keamanannya?”, belum bisa dijawab dengan pasti dan masih tetap mengambang.
Downloads
Download data is not yet available.
References
Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S, Hammar S. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med. 1996;334(18):1150-1155.
Rapola JM, Virtamo J, Ripatti S, Huttunen JK, Albanes D, Taylor PR, Heinonen OP. Randomised trial of alpha-tocopherol and beta-carotene supplements on incidence of major coronary events in men with previous myocardial infarction. Lancet. 1997;349(9067):1715-1720.
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha -Tocopherol, Beta Carotene Cancer Prevention Study Group. N Engl J Med. 1994;330(15):1029-1035.
Devaraj S, Tang R, Adams-Huet B, Harris A, Seenivasan T, de Lemos JA, Jialal I. Effect of high-dose alpha-tocopherol supple-mentation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease. Am J Clin Nutr. 2007;86(5):1392-1398.
Flores-Mateo G, Carrillo-Santisteve P, Elosua R, Guallar E, Marrugat J, Bleys J, Covas MI. Antioxidant enzyme activity and coronary heart disease: meta-analyses of observational studies. Am J Epidemiol. 2009;170(2):135-147.
Kang JH, Cook NR, Manson JE, Buring JE, Albert CM, Grodstein F. Vitamin E, vitamin C, beta carotene, and cogni-tive function among women with or at risk of cardiovascular disease: The Women’s Antioxidant and Cardiovascular Study. Circulation. 2009;119(21):2772-2780.
Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA. 2007;297(8):842-857.
Hasmain BI, Mooradian AD. Recent trials of antioxidant therapy: What should we be telling our patients? Cleveland Clinic J. 2004;71:327-334.
Rapola JM, Virtamo J, Ripatti S, Huttunen JK, Albanes D, Taylor PR, Heinonen OP. Randomised trial of alpha-tocopherol and beta-carotene supplements on incidence of major coronary events in men with previous myocardial infarction. Lancet. 1997;349(9067):1715-1720.
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha -Tocopherol, Beta Carotene Cancer Prevention Study Group. N Engl J Med. 1994;330(15):1029-1035.
Devaraj S, Tang R, Adams-Huet B, Harris A, Seenivasan T, de Lemos JA, Jialal I. Effect of high-dose alpha-tocopherol supple-mentation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease. Am J Clin Nutr. 2007;86(5):1392-1398.
Flores-Mateo G, Carrillo-Santisteve P, Elosua R, Guallar E, Marrugat J, Bleys J, Covas MI. Antioxidant enzyme activity and coronary heart disease: meta-analyses of observational studies. Am J Epidemiol. 2009;170(2):135-147.
Kang JH, Cook NR, Manson JE, Buring JE, Albert CM, Grodstein F. Vitamin E, vitamin C, beta carotene, and cogni-tive function among women with or at risk of cardiovascular disease: The Women’s Antioxidant and Cardiovascular Study. Circulation. 2009;119(21):2772-2780.
Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA. 2007;297(8):842-857.
Hasmain BI, Mooradian AD. Recent trials of antioxidant therapy: What should we be telling our patients? Cleveland Clinic J. 2004;71:327-334.
Views & Downloads
Abstract views: 4155
PDF (Bahasa Indonesia) downloads: 2775
PDF (Bahasa Indonesia) downloads: 2775
How to Cite
Baraas, F. (1). Manfaat Suplemen Antioksidan: Fakta atau Fiksi ?. Indonesian Journal of Cardiology, 32(1), 1-3. https://doi.org/10.30701/ijc.v32i1.113
Section
Editorial
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).