The Effect of Hiperbaric Oxygen Therapy on Vascular Endothelial Growth Factor (VEGF) level of Diabetic Ulcer patient
Abstract
Background. Hyperbaric oxygen therapy (HBOT) increase endothelial oxygenation and stimulates vascular endothelial growth factor(VEGF) as the most specific and potent growth factor for angiogenesis, and increases wound healing process. The aim of the study is to know if five days HBOT can increase the level of VEGF in diabetic ulcer patients.Methods and results. Clinical experimental study was conducted on 12 diabetic ulcer patients who received HBOT 30 minutes, 3 times a day for 5 days (HBOT group) and 10 diabetic ulcer patients as a control group who did not receive HBOT (non-HBOT group). The VEGF level in both groups was measured on days 1 and 5. In HBOT group the mean level of VEGF on day 1 was 1241.325 + 237.6533 pg/ml and became 1244.458 + 264.5641 pg/ml (p = 0.583) on day 5, while in non-HBOT group the mean level of VEGF on day 1 was 1262.350 + 227.9603 pg/ml and became 1112.460 + 220.3795 pg/ml (p = 0.093) on day 5. There were no signifi-cant differentiation of VEGF level between HBOT group and non-HBOT group both on day 1 (p = 1) and day 5 (p = 0.872)
Conclusions. Hyperbaric oxygen therapy for 5 days did not increase the VEGF level of diabetic ulcer patients.
Downloads
Download data is not yet available.
References
Stone JA, Cianci P. The adjunctive role of hyperbaric oxygen therapy in the treatment of lower extremity wounds in patients with diabetes. Diabetes spectrum. 1997;10:118-23.
Boyko EJ, Ahroni JH, Smith DG, Davignon D. Increased mor-tality associated with diabetic foot ulcer. Diabet Med. 1996;13:967-72.
Armstrong DG, Lavery LA. Diabetic foot ulcers: prevention, diagnosis and classification. American Family Physician. 1998;57:1-10.
Pinzur MS. Diabetic foot. 2004 . Available from : http://www.e-medicine.com
Frykberg RG. Diabetic foot ulcer: pathogenesis and manage-ment. Am Fam Physician. 2002;66:1655-62.
Tambunan M. Perawatan kaki diabetik. Materi penyuluhan. Dalam : Penatalaksanaan Diabetes Melitus Terpadu. Soegondo S, Soewondo P, Subekti I, editors. Balai Penerbit FKUI. Jakarta. 2002:293-8.
Roeckl-Wiedmann I, Bennett M, Kranke P. Systematic review of hyperbaric oxygen in the management of chronic wounds. Br J Surg. 2005;92:24-32.
Corral CJ, Siddiqui A, Wu L, Farrell CL, Lyons D, Mustoe TA. Vascular endothelial growth factor is more important than ba-sic fibroblast growth factor during ischemia wound healing. Arch Surg. 1999;134:200-5.
Bates DO, Jones ROP. The role of vascular endothelial growth factor in wound healing. Lower Extremity Wounds. 2003;2:107-20
Li VW, Li WW. The biology of PDGF and other growth factors in wound neovascularization. Contemp Surg. 2003;(suppl):12-8.
Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev. 2003;83:835-70.
Baba T, Shimada K, Neugebauer S, Yamada D, Hashimoto S, Watanabe T. The oral insulin sensitizer, thiazolidinedione, in-creases plasma, vascular endothelial growth factor in type 2 dia-betic patients. Diabetes Care. 2001;24:953-4
Guritno. Cost-effectiveness HBO therapy. In Update on hyper-baric oxygen therapy. Understanding challenges through HBO therapy, from pathology to clinical implication. 2005;3-9
Felmeden DC, Blann AD, Lip GYH. Angiogenesis: basic patho-physiology and implications for disease. Eur Heart J. 2003;24:586-603.
Sheikh AY, Gibson JJ, Rollins MD, Hopf HW, Hussain Z, Hunt TK. Effect of hyperoxia on vascular endothelial growth factor levels in a wound model. Arch Surg. 2000;135:1293-7.
Brauchle M, Funk JO, Kind P, Werner S. Ultraviolet B and H2O2 are potent inducers of vascular endothelial growth factor expression in cultured keratinocytes. J Biol Chem. 1996;271: 21793-7.
Wright J. Hyperbaric oxygen therapy for wound healing. Availbale from : http://www.worldwidewounds.com/2001/ april/ Wright/HyperbaricOxygen.html
Natarajan R, Bai W, Lanting L, Gonzales N, Nadler J. Effects of high glucose on vascular endothelial growth factor expres-sion in vascular smooth muscle cells. Heart Circ Physiol. 1997;42:H2224-31.
Hovind P, Tarnow L, Oestergaard PB, Parving HH. Elevated vascular endothelial growth factor in type 1 diabetic patients with diabetic nephropathy. Kidney Int. 2000;75:S56-S61.
Kessler L, Bilbault P, Ortega F, Grasso C, Passemard R, Stephan D, Pinget M, Schneider F. Hyperbaric oxygenation accelerates the healing rate of nonischemic chronic diabetic foot ulcers. A prospective randomized study. Diabetes Care. 2003;26:2378-82.
Dantz D, Bewersdorf J, Freuhwald-Schultes B, Kern W, Jelkmann W, Born J, Fehm HL, Peters A. Vascular endothelial growth factor : A novel endocrine defensive response to hy-poglycemia. J Clin Endocrinol Metab. 2002:87:835-40.
Ratnadewi N. Hubungan kadar vascular endothelial growth fac-tordengan faktor prognosis pada penderita karsinoma serviks uteri. Tesis program pendidikan dokter spesialis I. Universitas Padjadjaran Bandung. 2001.
Yamamoto Y, Toi M, Kondo S, Matsumoto T, Suzuki H, Kitamura M, Tsuruta K, et al. Concentrations of vascular en-dothelial growth factor in sera of normal control and cancer patients. Clinical Cancer Research. 1996;2:821-6.
Zheng A, Xia Y, Sun XF, Zhang CQ, Zhen ZJ, Wang ZH, Wang ZQ. Primary study of relationship between serum level of VEGF and non-Hodgkin’s lymphoma in children and ado-lescent patients. MedScape Today. 2004;23(11Suppl):1448-50.
Kang TS, Gorti GK, Quan SY, Ho M, Koch RJ. Effect of hyperbaric oxygen on the growth factor profile fibroblast. Arch Facial Plast Surg. 2004;6:31-5.
Singer AJ, Clark RAF. Cutaneous wound healing. N Engl J Med. 1999;341: 738-46.
Teas J, Cunningham JE, Cone L, Jansen K, Raghavan SK, Nitcheva DK, et al. Can hyperbaric oxygen therapy reduce breast cancer treatment-related lymphedema ?. A pilot study. J Women’s Health. 2004;13:1008-18.
Boyko EJ, Ahroni JH, Smith DG, Davignon D. Increased mor-tality associated with diabetic foot ulcer. Diabet Med. 1996;13:967-72.
Armstrong DG, Lavery LA. Diabetic foot ulcers: prevention, diagnosis and classification. American Family Physician. 1998;57:1-10.
Pinzur MS. Diabetic foot. 2004 . Available from : http://www.e-medicine.com
Frykberg RG. Diabetic foot ulcer: pathogenesis and manage-ment. Am Fam Physician. 2002;66:1655-62.
Tambunan M. Perawatan kaki diabetik. Materi penyuluhan. Dalam : Penatalaksanaan Diabetes Melitus Terpadu. Soegondo S, Soewondo P, Subekti I, editors. Balai Penerbit FKUI. Jakarta. 2002:293-8.
Roeckl-Wiedmann I, Bennett M, Kranke P. Systematic review of hyperbaric oxygen in the management of chronic wounds. Br J Surg. 2005;92:24-32.
Corral CJ, Siddiqui A, Wu L, Farrell CL, Lyons D, Mustoe TA. Vascular endothelial growth factor is more important than ba-sic fibroblast growth factor during ischemia wound healing. Arch Surg. 1999;134:200-5.
Bates DO, Jones ROP. The role of vascular endothelial growth factor in wound healing. Lower Extremity Wounds. 2003;2:107-20
Li VW, Li WW. The biology of PDGF and other growth factors in wound neovascularization. Contemp Surg. 2003;(suppl):12-8.
Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev. 2003;83:835-70.
Baba T, Shimada K, Neugebauer S, Yamada D, Hashimoto S, Watanabe T. The oral insulin sensitizer, thiazolidinedione, in-creases plasma, vascular endothelial growth factor in type 2 dia-betic patients. Diabetes Care. 2001;24:953-4
Guritno. Cost-effectiveness HBO therapy. In Update on hyper-baric oxygen therapy. Understanding challenges through HBO therapy, from pathology to clinical implication. 2005;3-9
Felmeden DC, Blann AD, Lip GYH. Angiogenesis: basic patho-physiology and implications for disease. Eur Heart J. 2003;24:586-603.
Sheikh AY, Gibson JJ, Rollins MD, Hopf HW, Hussain Z, Hunt TK. Effect of hyperoxia on vascular endothelial growth factor levels in a wound model. Arch Surg. 2000;135:1293-7.
Brauchle M, Funk JO, Kind P, Werner S. Ultraviolet B and H2O2 are potent inducers of vascular endothelial growth factor expression in cultured keratinocytes. J Biol Chem. 1996;271: 21793-7.
Wright J. Hyperbaric oxygen therapy for wound healing. Availbale from : http://www.worldwidewounds.com/2001/ april/ Wright/HyperbaricOxygen.html
Natarajan R, Bai W, Lanting L, Gonzales N, Nadler J. Effects of high glucose on vascular endothelial growth factor expres-sion in vascular smooth muscle cells. Heart Circ Physiol. 1997;42:H2224-31.
Hovind P, Tarnow L, Oestergaard PB, Parving HH. Elevated vascular endothelial growth factor in type 1 diabetic patients with diabetic nephropathy. Kidney Int. 2000;75:S56-S61.
Kessler L, Bilbault P, Ortega F, Grasso C, Passemard R, Stephan D, Pinget M, Schneider F. Hyperbaric oxygenation accelerates the healing rate of nonischemic chronic diabetic foot ulcers. A prospective randomized study. Diabetes Care. 2003;26:2378-82.
Dantz D, Bewersdorf J, Freuhwald-Schultes B, Kern W, Jelkmann W, Born J, Fehm HL, Peters A. Vascular endothelial growth factor : A novel endocrine defensive response to hy-poglycemia. J Clin Endocrinol Metab. 2002:87:835-40.
Ratnadewi N. Hubungan kadar vascular endothelial growth fac-tordengan faktor prognosis pada penderita karsinoma serviks uteri. Tesis program pendidikan dokter spesialis I. Universitas Padjadjaran Bandung. 2001.
Yamamoto Y, Toi M, Kondo S, Matsumoto T, Suzuki H, Kitamura M, Tsuruta K, et al. Concentrations of vascular en-dothelial growth factor in sera of normal control and cancer patients. Clinical Cancer Research. 1996;2:821-6.
Zheng A, Xia Y, Sun XF, Zhang CQ, Zhen ZJ, Wang ZH, Wang ZQ. Primary study of relationship between serum level of VEGF and non-Hodgkin’s lymphoma in children and ado-lescent patients. MedScape Today. 2004;23(11Suppl):1448-50.
Kang TS, Gorti GK, Quan SY, Ho M, Koch RJ. Effect of hyperbaric oxygen on the growth factor profile fibroblast. Arch Facial Plast Surg. 2004;6:31-5.
Singer AJ, Clark RAF. Cutaneous wound healing. N Engl J Med. 1999;341: 738-46.
Teas J, Cunningham JE, Cone L, Jansen K, Raghavan SK, Nitcheva DK, et al. Can hyperbaric oxygen therapy reduce breast cancer treatment-related lymphedema ?. A pilot study. J Women’s Health. 2004;13:1008-18.
Views & Downloads
Abstract views: 3005
PDF (Bahasa Indonesia) downloads: 2190
PDF (Bahasa Indonesia) downloads: 2190
How to Cite
Akbar, M., Kaligis, R., & Kasim, M. (1). The Effect of Hiperbaric Oxygen Therapy on Vascular Endothelial Growth Factor (VEGF) level of Diabetic Ulcer patient. Indonesian Journal of Cardiology, 28(1), 53-59. https://doi.org/10.30701/ijc.v28i1.267
Section
Clinical Research
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
