Correlation Between The Level of Lp-PLA2, MDA, F2- Isp in Serum And Aortic Tissue With The Number of Foam Cells at Atherogenesis Process in Wistar Rats
Abstract
Background. Atherogenesiswas initiated by cholesterol deposits on foam cell in sub intimae of blood vessel stress oxidation. Atherogenesis in non- hypercolesterolemiausually undergoes an increased level of Lp-PLA2. It, therefore, needs to evaluate the role of Lp-PLA2in the foam cell formation. Aims. To explain the role of Lp-PLA2 in the foam cell forming, to correlate the level of Lp-PLA2 ,MDA, F2-Isp in aorta with foam cell number (FCs) as well as to correlate the level of Lp-PLA2 , MDA, F2-Isp contents in serum
with their contents in aorta and the correlation with FCs.
Methods. 30 rats aged 2 months, with their weight averaging from 150-200g,
were divided into the control group and the treatment one where the latter
was fed hyperlidemia for 2,8 and 12 weeks. The measurement level of LDL-C,
MDA, F2-isp and Lp-PLA2in serum was performedas well as aorta and FCs. Data was analysed using anova, t-Test, path analysis and correlation. Results. Research result indicated that: (1) The level of MDA(a), F2-Isp(s) and Lp-PLA2(s) positively correlated with FCs, Lp-PLA(s)having the highest
correlation value. (2) Lp-PLA2(a),MDA(s) and F2-Isp(s,a)did not correlate with
FCs. (3) There was a positive correlation between Lp-PLA2 with MDA and
F2-Isp in both serum and aorta.
Conclusion. The enzyme of Lp-PLA2 acts as an activator in forming the
foam cell with stimulated stress oxidation.Downloads
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