Dapatkah Matrix Metalloproteinase Memprediksi Luasnya Kerusakan Miokard?
Abstract
Trombosis arteri merupakan dasar terjadinya sindrom koroner akut. Sebagian besar trombosis terjadi pada robekan plak pada bagian fibrous cap yang tipis. Plak aterom yang memiliki fibrous cap yang tipis dan mudah mengalami robekan sering disebut sebagai vulnerable plaque. Penting dicatat bahwa derajat stenosis plak yang mengalami robekan seringkali hanya ringan atau sedang saja.3 Para peneliti berhipotesis bahwa kehilangan komponen matriks khususnya serabut kolagen pada fibrous cap menyebabkan penipisan cap. Hal ini akan memudahkan terjadinya robekan baik secara spontan maupun sebagai respon terhadap trigger hemodinamik ata yang lainya.Matrix metalloproteinases (MMPs) agaknya memainkan peran penting dalam remodeling plak aterosklerotik, walaupun berbagai bukti menunjukkan hubungan peningkatan MMP dengan terjadinya instabilitas plak masih kontroversial.
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References
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Little WC. Angiographic assessment of the culprit coronary artery lesion before acute myocardial infarction. Am J Cardiol. 1990;66(16):44G-47G.
Fishbein MC, Siegel RJ. How big are coronary atherosclerotic plaques that rupture? Circulation. 1996;94(10):2662-2666.
Shah PK, Falk E, Badimon JJ, Fernandez-Ortiz A, Mailhac A, Villareal-Levy G, Fallon JT, Regnstrom J, Fuster V. Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture. Circulation. 1995;92(6):1565-1569.
Dollery CM, McEwan JR, Henney AM. Matrix metallopro-teinases and cardiovascular disease. Circ Res. 1995;77(5):863-6. Shah PK. Mechanisms of plaque vulnerability and rupture. J Am Coll Cardiol. 2003;41(4 Suppl S):15S-22S.
George SJ, Zaltsman AB, Newby AC. Surgical preparative injury and neointima formation increase MMP-9 expression and MMP-2 activation in human saphenous vein. Cardiovasc Res. 1997;33(2):447-459.
Nikkari ST, Geary RL, Hatsukami T, Ferguson M, Forough R, Alpers CE, Clowes AW. Expression of collagen, interstitial colla-genase, and tissue inhibitor of metalloproteinases-1 in restenosis after carotid endarterectomy. Am J Pathol. 1996;148(3):777-9.
Setianto BY, Astuti I, Irawan B, Mubarika S. Hubungan antara kadar MMP-9 dengan kadar troponin-I pada infark miokard dengan ST-elevasi dan sindom koroner akut tanpa ST-elevasi. J Kardiol Indones. 2011;32(1):4-12.
Moon SK, Cho GO, Jung SY, Gal SW, Kwon TK, Lee YC, Madamanchi NR, Kim CH. Quercetin exerts multiple inhibi-tory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9. Biochem Biophys Res Commun. 2003;301(4):1069-1078.
Little WC. Angiographic assessment of the culprit coronary artery lesion before acute myocardial infarction. Am J Cardiol. 1990;66(16):44G-47G.
Fishbein MC, Siegel RJ. How big are coronary atherosclerotic plaques that rupture? Circulation. 1996;94(10):2662-2666.
Shah PK, Falk E, Badimon JJ, Fernandez-Ortiz A, Mailhac A, Villareal-Levy G, Fallon JT, Regnstrom J, Fuster V. Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture. Circulation. 1995;92(6):1565-1569.
Dollery CM, McEwan JR, Henney AM. Matrix metallopro-teinases and cardiovascular disease. Circ Res. 1995;77(5):863-6. Shah PK. Mechanisms of plaque vulnerability and rupture. J Am Coll Cardiol. 2003;41(4 Suppl S):15S-22S.
George SJ, Zaltsman AB, Newby AC. Surgical preparative injury and neointima formation increase MMP-9 expression and MMP-2 activation in human saphenous vein. Cardiovasc Res. 1997;33(2):447-459.
Nikkari ST, Geary RL, Hatsukami T, Ferguson M, Forough R, Alpers CE, Clowes AW. Expression of collagen, interstitial colla-genase, and tissue inhibitor of metalloproteinases-1 in restenosis after carotid endarterectomy. Am J Pathol. 1996;148(3):777-9.
Setianto BY, Astuti I, Irawan B, Mubarika S. Hubungan antara kadar MMP-9 dengan kadar troponin-I pada infark miokard dengan ST-elevasi dan sindom koroner akut tanpa ST-elevasi. J Kardiol Indones. 2011;32(1):4-12.
Moon SK, Cho GO, Jung SY, Gal SW, Kwon TK, Lee YC, Madamanchi NR, Kim CH. Quercetin exerts multiple inhibi-tory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9. Biochem Biophys Res Commun. 2003;301(4):1069-1078.
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How to Cite
Yuniadi, Y. (1). Dapatkah Matrix Metalloproteinase Memprediksi Luasnya Kerusakan Miokard?. Indonesian Journal of Cardiology, 32(1), 12-13. https://doi.org/10.30701/ijc.v32i1.115
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