Gap Junctions in Ischemia-Related Ventricular Arrhythmia
Abstract
Cardiovascular diseases are the leading cause of death worldwide, with isch-emic heart disease being the most common entity. Ventricular arrhythmia is one of the complications of ischemia that can result in sudden cardiac death. One of the underlying mechanisms of ischemia induced arrhythmia is closure of cardiac myocytes gap junctions, where gap junctions are channel-like structure between cells that allow passage of molecules and electrical current. During ischemia, gap junctions close incompletely, creating tissue impedance heterogeneity and conduction slowing, which provide substrate for ventricular arrhythmia. Conditions where gap junctions structure is altered, such as in heart failure, is associated with increased vulnerability of ischemia-induced ventricular arrhythmia.Downloads
Download data is not yet available.
References
World Health Organization. The global burden of disease: 2004 update. 2008
Zipes DP, Wellens HJ. Sudden cardiac death. Circulation. 1998;98:2334-2351
Medline. Medical subject heading. 2010;2010
Delmar M, Duffy HS, Sorgen PL, Taffet SM, Spray DC. Mo-lecular organization and regulation of the cardiac gap junction channel connexin43 In: Zipes DP, Jalife J, eds. Cardiac electro-physiology: From cell to bedside. Saunders; 2004.
Revel JP, Karnovsky MJ. Hexagonal array of subunits in in-tercellular junctions of the mouse heart and liver. J Cell Biol.1967;33:C7-C12
Perkins G, Goodenough D, Sosinsky G. Three-dimensional structure of the gap junction connexon. Biophys J. 1997;72:533
Duffy HS. Cardiac connections--the antiarrhythmic solution? N Engl J Med. 2008;358:1397-1398
Zipes DP, Wellens HJ. Sudden cardiac death. Circulation. 1998;98:2334-2351
Medline. Medical subject heading. 2010;2010
Delmar M, Duffy HS, Sorgen PL, Taffet SM, Spray DC. Mo-lecular organization and regulation of the cardiac gap junction channel connexin43 In: Zipes DP, Jalife J, eds. Cardiac electro-physiology: From cell to bedside. Saunders; 2004.
Revel JP, Karnovsky MJ. Hexagonal array of subunits in in-tercellular junctions of the mouse heart and liver. J Cell Biol.1967;33:C7-C12
Perkins G, Goodenough D, Sosinsky G. Three-dimensional structure of the gap junction connexon. Biophys J. 1997;72:533
Duffy HS. Cardiac connections--the antiarrhythmic solution? N Engl J Med. 2008;358:1397-1398
Views & Downloads
Abstract views: 3210
PDF downloads: 3129
PDF downloads: 3129
How to Cite
Idris, B., & Yuniadi, Y. (1). Gap Junctions in Ischemia-Related Ventricular Arrhythmia. Indonesian Journal of Cardiology, 32(1), 53-60. https://doi.org/10.30701/ijc.v32i1.123
Section
Review Article
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
