Riset Translasional: Sebuah Pelajaran dari Malang
Abstract
Dalam beberapa dekade terakhir ini, terjadi 'ledakan' penemuan dalam riset biomedis, termasuk selesainya pembacaan sekuens keseluruhan genom manusia sekitar satu dekade yang lalu. Namun, sebagian besar temuan biomedis ini belum berhasil dimanfaatkan dalam praktek klinik, baik untuk peningkatan diagnosis maupun terapi.Banyak kendala yang menyebabkan lambatnya translasi dari penemuan biomedis (riset dasar) ke aplikasi klinik. Di antara berbagai kendala, faktor yang palingkrusial adalah kenyataan bahwa proses translasi tersebut tidak ada yang sederhana.Translasi memerlukan proses riset yang kontinyu baik di tingkat klinik maupun di laboratorium. Selain itu, diperlukan juga adanya 'jembatan' yang menghubungkan kedua jenis riset tersebut, karena faktanya ada perbedaan mendasar antara riset klinik dan riset biomedis (dasar).
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References
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Nathan DG. Careers in translational clinical research-historical perspectives, future challenges. JAMA 2002;287:2424-2427.
Hennekens CH, Gaziano JM, Manson JE, Buring JE. Antioxidant vitamin-cardiovascular disease hypothesis is still promising, but still unproven: the need for randomized trials. Am J Clin Nutr 1995;62:1377S-1380S.
Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol. Modifications of low-densitylipoprotein that increase its atherogenicity. N Engl J Med 1989;320:915-924.
Kris-Etherton PM, Lichtenstein AH, Howard BV, Steinberg D, Witztum JL. Antioxidant vitamin supplements and cardiovascular disease. Circulation 2004;110:637-641.
Goldstein JL, Brown MS. The clinical investigator: bewitched, bothered, and bewildered--but still beloved. J ClinInvest 1997;99:2803-2812
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How to Cite
Raharjo, S. (1). Riset Translasional: Sebuah Pelajaran dari Malang. Indonesian Journal of Cardiology, 33(4), 215-6. https://doi.org/10.30701/ijc.v33i4.24
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