Right Ventricular Dysfuction In Subject With Obstructive Sleep Apnoea
Abstract
An analytical design study on the systolic right ventricle (RV) functionwas done in Obstructive Sleep Apnea (OSA) patients who underwent
polisomnography procedure and compare it with normal subject. The
assessment of the RV function was performed using the Speckle tracking
echocardiography method. Other RV function parameters such as TAPSE,
Tissue Doppler Imaging (TDI), dan Myocardial Performance Index (MPI)
were also measured.
The results showed RV dysfunction in OSA patients compared with normal
subject, the decrease of RV function was significantly different between
the two groups. Factors that contributed to RV dysfunction in OSA patients
were higher Apnea-Hypopnea Index (AHI) and Nocturnal Oxygen
Desaturation.
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References
Somers VK, White DP, Amin R, et al. Sleep apnea and cardiovascular
disease: an American Heart Association/American
College of Cardiology Foundation Scientific Statement from the
American Heart Association Council for High Blood Pressure
Research Professional Education Committee, Council on Clinical
Cardiology, Stroke Council, and Council on Cardiovascular
Nursing. J Am Coll Cardiol 2008;52:686-717.
Kato M, Adachi T, Koshino Y, Somers VK. Obstructive sleep
apnea and cardiovascular disease. Circ J 2009;73:1363-70.
Leung RS, Bradley TD. Sleep apnea and cardiovascular disease.
Am J Respir Crit Care Med 2001;164:2147-65.
Tavil Y, Kanbay A, Sen N, et al. Comparison of right ventricular
functions by tissue Doppler imaging in patients with obstructive
sleep apnea syndrome with or without hypertension. Int J
Cardiovasc Imaging 2007;23:469-77.
Dursunoglu N, Dursunoglu D, Kilic M. Impact of obstructive
sleep apnea on right ventricular global function: sleep apnea and
myocardial performance index. Respiration 2005;72:278-84.
Matias C, Isla LP, Vasconcelos M, et al. Speckle-tracking-derived
strain and strain-rate analysis: a technique for the evaluation of
early alterations in right ventricle systolic function in patients
with systemic sclerosis and normal pulmonary artery pressure.
J Cardiovasc Med (Hagerstown) 2009;10:129-34.
Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The
occurrence of sleep-disordered breathing among middle-aged
adults. N Engl J Med 1993;328:1230-5.
Bixler EO, Vgontzas AN, Lin HM, et al. Prevalence of sleepdisordered
breathing in women: effects of gender. Am J Respir
Crit Care Med 2001;163:608-13.
Horner RL, Mohiaddin RH, Lowell DG, et al. Sites and sizes
of fat deposits around the pharynx in obese patients with obstructive
sleep apnoea and weight matched controls. Eur Respir
J 1989;2:613-22.
Jurcut R, Giusca S, Ticulescu R, et al. Different patterns of adaptation
of the right ventricle to pressure overload: a comparison
between pulmonary hypertension and pulmonary stenosis. J Am
Soc Echocardiogr 2011;24:1109-17.
Kasai T, Bradley TD. Obstructive sleep apnea and heart failure:
pathophysiologic and therapeutic implications. J Am Coll Cardiol
2011;57:119-27.
Romero-Corral A, Somers VK, Pellikka PA, et al. Decreased
right and left ventricular myocardial performance in obstructive
sleep apnea. Chest 2007;132:1863-70.
Nageh MF, Kopelen HA, Zoghbi WA, Quinones MA, Nagueh
SF. Estimation of mean right atrial pressure using tissue Doppler
imaging. Am J Cardiol 1999;84:1448-51, A8.
Dandel M, Hetzer R. Echocardiographic strain and strain rate
imaging--clinical applications. Int J Cardiol 2009;132:11-24.
Meris A, Faletra F, Conca C, et al. Timing and magnitude of
regional right ventricular function: a speckle tracking-derived
strain study of normal subjects and patients with right ventricular
dysfunction. J Am Soc Echocardiogr 2010;23:823-31.
Rudski LG, Lai WW, Afilalo J, et al. Guidelines for the echocardiographic
assessment of the right heart in adults: a report from
the American Society of Echocardiography endorsed by the
European Association of Echocardiography, a registered branch
of the European Society of Cardiology, and the Canadian Society
of Echocardiography. J Am Soc Echocardiogr 2010;23:685-713;
quiz 86-8.
Kukulski T, Voigt JU, Wilkenshoff UM, et al. A comparison
of regional myocardial velocity information derived by pulsed
and color Doppler techniques: an in vitro and in vivo study.
Echocardiography 2000;17:639-51.
Nahmias J, Lao R, Karetzky M. Right ventricular dysfunction in
obstructive sleep apnoea: reversal with nasal continuous positive
airway pressure. Eur Respir J 1996;9:945-51.
Laks L, Lehrhaft B, Grunstein RR, Sullivan CE. Pulmonary hypertension
in obstructive sleep apnoea. Eur Respir J 1995;8:537-
41.
Sajkov D, McEvoy RD. Obstructive sleep apnea and pulmonary
hypertension. Prog Cardiovasc Dis 2009;51:363-70.
disease: an American Heart Association/American
College of Cardiology Foundation Scientific Statement from the
American Heart Association Council for High Blood Pressure
Research Professional Education Committee, Council on Clinical
Cardiology, Stroke Council, and Council on Cardiovascular
Nursing. J Am Coll Cardiol 2008;52:686-717.
Kato M, Adachi T, Koshino Y, Somers VK. Obstructive sleep
apnea and cardiovascular disease. Circ J 2009;73:1363-70.
Leung RS, Bradley TD. Sleep apnea and cardiovascular disease.
Am J Respir Crit Care Med 2001;164:2147-65.
Tavil Y, Kanbay A, Sen N, et al. Comparison of right ventricular
functions by tissue Doppler imaging in patients with obstructive
sleep apnea syndrome with or without hypertension. Int J
Cardiovasc Imaging 2007;23:469-77.
Dursunoglu N, Dursunoglu D, Kilic M. Impact of obstructive
sleep apnea on right ventricular global function: sleep apnea and
myocardial performance index. Respiration 2005;72:278-84.
Matias C, Isla LP, Vasconcelos M, et al. Speckle-tracking-derived
strain and strain-rate analysis: a technique for the evaluation of
early alterations in right ventricle systolic function in patients
with systemic sclerosis and normal pulmonary artery pressure.
J Cardiovasc Med (Hagerstown) 2009;10:129-34.
Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The
occurrence of sleep-disordered breathing among middle-aged
adults. N Engl J Med 1993;328:1230-5.
Bixler EO, Vgontzas AN, Lin HM, et al. Prevalence of sleepdisordered
breathing in women: effects of gender. Am J Respir
Crit Care Med 2001;163:608-13.
Horner RL, Mohiaddin RH, Lowell DG, et al. Sites and sizes
of fat deposits around the pharynx in obese patients with obstructive
sleep apnoea and weight matched controls. Eur Respir
J 1989;2:613-22.
Jurcut R, Giusca S, Ticulescu R, et al. Different patterns of adaptation
of the right ventricle to pressure overload: a comparison
between pulmonary hypertension and pulmonary stenosis. J Am
Soc Echocardiogr 2011;24:1109-17.
Kasai T, Bradley TD. Obstructive sleep apnea and heart failure:
pathophysiologic and therapeutic implications. J Am Coll Cardiol
2011;57:119-27.
Romero-Corral A, Somers VK, Pellikka PA, et al. Decreased
right and left ventricular myocardial performance in obstructive
sleep apnea. Chest 2007;132:1863-70.
Nageh MF, Kopelen HA, Zoghbi WA, Quinones MA, Nagueh
SF. Estimation of mean right atrial pressure using tissue Doppler
imaging. Am J Cardiol 1999;84:1448-51, A8.
Dandel M, Hetzer R. Echocardiographic strain and strain rate
imaging--clinical applications. Int J Cardiol 2009;132:11-24.
Meris A, Faletra F, Conca C, et al. Timing and magnitude of
regional right ventricular function: a speckle tracking-derived
strain study of normal subjects and patients with right ventricular
dysfunction. J Am Soc Echocardiogr 2010;23:823-31.
Rudski LG, Lai WW, Afilalo J, et al. Guidelines for the echocardiographic
assessment of the right heart in adults: a report from
the American Society of Echocardiography endorsed by the
European Association of Echocardiography, a registered branch
of the European Society of Cardiology, and the Canadian Society
of Echocardiography. J Am Soc Echocardiogr 2010;23:685-713;
quiz 86-8.
Kukulski T, Voigt JU, Wilkenshoff UM, et al. A comparison
of regional myocardial velocity information derived by pulsed
and color Doppler techniques: an in vitro and in vivo study.
Echocardiography 2000;17:639-51.
Nahmias J, Lao R, Karetzky M. Right ventricular dysfunction in
obstructive sleep apnoea: reversal with nasal continuous positive
airway pressure. Eur Respir J 1996;9:945-51.
Laks L, Lehrhaft B, Grunstein RR, Sullivan CE. Pulmonary hypertension
in obstructive sleep apnoea. Eur Respir J 1995;8:537-
41.
Sajkov D, McEvoy RD. Obstructive sleep apnea and pulmonary
hypertension. Prog Cardiovasc Dis 2009;51:363-70.
Published
2015-03-31
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How to Cite
Santoso, R., Rahajoe, A., & Sunu, I. (2015). Right Ventricular Dysfuction In Subject With Obstructive Sleep Apnoea. Indonesian Journal of Cardiology, 34(4), 210-9. https://doi.org/10.30701/ijc.v34i4.379
Section
Clinical Research
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