Gangguan Kardiovaskular pada Infeksi COVID 19
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) yang dikenal dengan COVID-19 adalah penyakit yang baru dan telah menyebar dengan cepat dari Wuhan (provinsi Hubei) ke provinsi lain di Cina dan seluruh dunia termasuk Indonesia. Secara umum, COVID-19 adalah penyakit akut yang bisa sembuh tetapi juga mematikan, dengan case fatality rate (CFR) sebesar 4%. Spektrum klinis pneumonia COVID-19 berkisar dari kondisi ringan sampai dengan berat. COVID 19 diduga memiliki risiko potensiasi proses patofisiologi terhadap timbulnya komplikasi kardiak, dan telah diketahui bahwa mekanisme penyakit kardiovaskular serupa dengan mekanisme jalur imunologi. Penyakit kardiovaskular adalah komorbid terbanyak pada pasien COVID 19, SARS, dan MERS. Prevalensi diabetes mellitus (DM) dan penyakit kardiovaskular pada SARS adalah 11% dan 8% dan membawa angka kematian meningkat 2 kali lipat. Pada kasus COVID 19, komorbid penyakit kardiovaskular lebih banyak menunjukkan kasus yang berat. Bagaimana mekanisme komorbid ini memperburuk keluaran pasien masih tidak jelas, namun beberapa hipotesisnya antara lain usia lanjut, gangguan sistem imun, peningkatan kadar ACE2 atau mungkin ada hubungan antara COVID 19 dengan penyakit kardiovaskular. Tinjauan pustaka ini akan menjelaskan berbagai gangguan kardiovaskular yang mungkin terjadi pada infeksi COVID 19 secara lebih mendalam.
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References
2. Clerkin KJ, Fried JA, Raikhelkar J, Sayer G, Griffin JM, Masoumi A, et al. Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease. Circulation. 2020.
3. Corrales-Medina VF, Musher DM, Shachkina S, Chirinos JA. Acute pneumonia and the cardiovascular system. The Lancet. 2013;381(9865):496-505.
4. Driggin E, Madhavan MV, Bikdeli B, Chuich T, Laracy J, Bondi-Zoccai G, et al. Cardiovascular considerations for patients, health care workers, and health systems during the coronavirus disease 2019 (COVID-19) pandemic. Journal of the American College of Cardiology. 2020.
5. Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O. Potential Effects of Coronaviruses on the Cardiovascular System: A Review. JAMA cardiology. 2020.
6. Zheng Y-Y, Ma Y-T, Zhang J-Y, Xie X. COVID-19 and the cardiovascular system. Nature Reviews Cardiology. 2020:1-2.
7. Xiong T-Y, Redwood S, Prendergast B, Chen M. Coronaviruses and the cardiovascular system: acute and long-term implications. European Heart Journal. 2020.
8. Mehra MR, Ruschitzka F. COVID-19 Illness and Heart Failure: A Missing Link? : JACC: Heart Failure; 2020.
9. Mitra RL GS, Epstein, LM. An algorithm for managing QT prolongation in Coronavirus Disease 2019 (COVID-19) patients treated with either chloroquine or hydroxychloroquine in conjunction with azithromycin: Possible benefits of intravenous lidocaine. Elsevier. 2020.
10. Krahn A BD, Chow CM, Clarke B. COVID-19 and cardiovascular disease : what the cardiac healthcare provider should know. Canadian Cardiovascular Society. 2020.
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